(Goserelin) contains a potent synthetic decapeptide analogue of luteinizing hormone-releasing hormone which is
shown to be useful in the treatment of prostate cancer. Goserelin is an off-white powder with a molecular weight
of 1269 free base.
Indications: Zoladex comes in tablets form. The medication is often
indicated in the treatment of prostate cancer in men and for breast cancer in women. It is also indicated in endometriosis
(uterus disorder). Goserelin is a similar natural hormone which works by decreasing the testosterone hormones in
men and oestrogen hormones in women. Testosterones are the male hormones that help cancerous cells in their
growth. Zoladex reduces the growth of these hormones, consecutively inhibiting proliferation of the malignancy.
Dosage: Zoladex is usually given as an injection in the dosage of
3.6 milligram for 4 weeks or 10.8 milligram for 12 weeks. The dosage schedule of this drug has to be followed
strictly in order to achieve desired results. Hormone levels tend to increase usually during the first few weeks
of the treatment. This is a normal indication because hormone levels start decreasing during the consequent
course of this drug. The 10.8 milligram dosage should not be used in women and it is prescribed only for men.
Zoladex is also supplied as a sterile, biodegradable product consisting of Goserelin acetate, equivalent to a
3.6 mg of Goserelin to be administered every 28 days.
Contraindications: Zoladex (Goserelin) may face contraindications in
This drug should not be taken if the
patient is suffering from diabetes as the drug decreases the control of blood sugar levels. In such
cases monitoring of sugar levels becomes important.
If the patient is having a family
history of osteoporosis (bone loss)
Spinal cord problems or urinary
blockage in men
Long term usage of alcohol,
If the patient is allergic to the
drug, or any of its components, its intake must be ceased.
Therefore, before the
commencement of the treatment, the doctor should be informed about the complete medical history of the
Mechanism of Action
(MOA): Zoladex being an analogue
of natural event LHRH, with its incessant administration results in a major turn down in testosterone production
by the testicles. This reduces testosterone’s encouragement to development or proliferation of prostate cancer.
In women, it reduces the growth of oestrogen hormones and prevents them from associated
Interactions: The use of vitamins or herbal products, minerals, and the
prescriptions given by other doctors may interact with this drug.
Zoladex may cause some of the following
common side effects that may cease after patient’s body gets accustomed to this drug:
Pain in bones and
Eruption of symptomatic signs of
prostatic cancer, known as the tumour flare effect, due to the amplification in the production of
Hot flushes, rashes, hives and
eruptions on skin
Headache, lethargy, stomach ache,
acidity, and depression
Sudden gain in weight gain and
tenderness of breasts
Poor libido and painful
If any of these side
effects are persistent even after ceasing the intake of Zoladex, doctor must be consulted at earliest to prevent
complications that can worsen the cancer.