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Terazosin (Hytrin)  

High blood pressure (hypertension) can be treated using the drug Terazosin which is also known as Hytrin. Terazosin is mainly a vasodilator and also an alpha-adrenergic antagonist. It is shown to be effective a variety of BPH symptoms. Terazosin is also useful in lowering blood pressure levels as it is effective enough in relaxing and expanding blood vessels.  

Indications: Terazosin is mainly prescribed for the treatment of Benign Prostatic Hyperplasia (BPH). Unlike some BPH medications, the effective results of this drug can be very quickly seen. After a short period, more than 70% of the patients immediately see positive changes after taking this medication with increase in the flow of urine. However, the long term side effects of this drug have not been recorded yet.  

In addition to prostatic problems, hypertension is another ailment that can be treated with this drug. Terazosin can be used singly or in combination with other common diuretics or any other blocking agents (beta-adrenergic) to help people keep their blood pressure at normal levels.  

Dosage: I n the treatment of BPH, the initial dosage must be 1mg during bedtime. Thereafter, the health care provider would have to closely observe any kind of hypertensive response. Consequently, the dosage is to be increased accordingly, like – 2mg, 4mg....10mg. This increment of dosage has to be done to regain the normal flow rate of the urine. For clinical responses, a dosage of 10mg can be prescribed. Still a patient has to intake the drug for a minimum of 5 to 6 weeks in order to experience the desired results. A dosage of 20mg is also considered effective but no perfect conclusion has been drawn so far. 

In high blood pressure treatment, an initial dosage of 1mg is required to treat a patient with this disease. After closely monitoring the patient for any discomforts, the dosage of the drug should be increased to a higher level. The drug should be given once a day and with a fixed time interval. Often it has been seen that patients taking 20mg of this drug feel the relaxing effect. This needs to be strictly monitored and then considered in accordance to the blood pressure of the patient.

Contraindications: Terazosin contraindication is only recommended to patients who are very much sensitive to terazosin hydrochloride. 

Mechanism of Action (MOA): In the case of hypertension, Terazosin produces the effect of vasodilatation and thereafter reduces any form of peripheral resistance. In this course, there is almost no effect on cardiac output. The filtration rate of the renal flow also remains unaffected. In the case of BPH, the production of the 1-adrenargic blockage eases any form of urethral resistance along with other urinary ailments.   

Interactions: Before using Terazosin, inform doctor about all those medicines that are already being taken. Care should be taken in case patients are taking drugs for lowering blood pressure and urination problems. The drug may interact when taken along with certain medications like antihistamines, muscle relaxants, narcotic pain relievers, psychiatric medicines, aspirin, advair diskus, celebex, or anti-depressants.   

Side Effects: the drug causes side effects in most users. Overdosing Terazosin may lead to serious adverse effects which may include: fast heartbeat, fainting spells, swelling of palms or feet, penile erection, headache, weakness, fatigue, stuffy nose or chest congestion.