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Rocephin (Ceftriaxone)  

Also known as the Ceftriaxone, Rocephin is a drug which belongs to the cephalosporin class, a group of antibiotics originally derived from the fungus Acremonium. It is mainly antibiotic in nature and very effective in protecting human body against any bacterial infection. Rocephin is mainly used to treat or prevent against any infectious growth. Meningitis, a life threatening disease, is controlled by the usage of this drug. Apart from resisting these infections, there are many other uses of this drug too.  

Indications: Rocephin is one drug that is commonly prescribed to treat different types of infection in human body. It is used to treat the respiratory tract (mainly the lower part) infections, as well as ottis media, inflammation or infection of the middle ear . These two ailments are mainly caused by pneumonia. While treating any oral infections, it is highly advisable to observe the effects before taking this drug at a regular basis. Rocephin is also very useful in curing certain skin infections. UTI and also Gonorrhea can also be treated using Rocephin . The pelvic infections, abdominal infections, joint or bone infections can also be treated by Ceftriaxone . Meningitis is another ailment which can be treated by this drug.   

Dosage: The dosage of Rocephin is different for various age groups. New born babies should be never given this drug. For pediatric group, the dosage would be around 60mg/kg. It should be noted that the total dosage must not scale over 2 gm. If a pediatric patient is suffering from acute meningitis, the dosage can be increased to a maximum level of 2gm per 24 hours. However, the dosage can be divided into two parts and can be given alternatively after 12 hours. Generally, with this rate of dosage it takes around a week to get completely cured. In case of adults the dosage gets increased to around 1 to 2 gm per day. For serious internal infection like Gonorrhea single dosage of 250mg should be injected inside the body.   

Contraindications: Rocephin can be used by all age groups except for the premature group. The premature babies, less than the age of 28 days, are hypersensitive to this drug and must not be given it.  

Mechanism of Action (MOA): Ceftriaxone gets bounded to one or more penicillin-binding proteins that inhibit the synthesis in bacterial cell wall. This consequently stalls biosynthesis of cell wall and causes bacterial cell death. 

Absorption - After 2 hours 

Distribution – Gets widely distributed inside body fluids, tissues and therapeutic concentrations. Its protein-binding is 85 to 95%. 

Excretion – 40 to 65 % of Rocephin gets excreted through urine and the remaining is excreted via faeces (as microbiologically inactive compounds). Its elimination half-life is 6 to 9 hours.  

Interactions: Following are some of the drugs that cannot be combined with Rocephine:

  • aspirin
  • Cipro (ciprofloxacin)
  • azithromycin
  • ciprofloxacin
  • Flagyl (metronidazole)
  • doxycycline
  • furosemide
  • Lasix (furosemide)
  • gabapentin
  • Levaquin (levofloxacin)
  • metformin
  • lisinopril
  • metoprolol 

Side effects: Some of the side effects caused by Rocephin include: 

  • Bloody or watery diarrhea 
  • Feverish feeling 
  • Peeling of skin along with blistering 
  • White sores all over the body 
  • Yellowish urine 
  • Low volume of urine 
  • Stomach pain 
  • Nausea  
  • Swelling