Ofloxacin is a powerful
chemotherapeutic drug that is antibiotic in nature (cytotoxic antibiotic or antimicrobial chemotherapy).
This medication is now available under several brand names for intravenous and oral administration. Floxin is
available for relevant use as eye and ear drops.
Indications: Ofloxacin is mainly indicated in in treatment of prostate
infection (Prostatis). It is used in small dosages in adults to treat serious bacterial infections like the
inflammation of the prostate gland. When there is swelling of the prostate gland, it increases pressure felt by
the adjoining tissues. This leads to trouble in urinating along with other problems like fainting while
urinating; burning sensation in urethra, painful ejaculation, etc. This medication alleviates all these
problems, making the life of the patient better.
Ofloxacin is also used in
the treatment of several other bacterial infections:
Bacterial exacerbations in chronic
Several skin infections
Infections in urethra and
Acute pelvic inflammatory
Urinary tract infections and
Dosage: The drug, Ofloxacin, should be administered as per the
recommendation and prescription of medical practitioner. The usual duration for which the drug is administered
is 7 – 14 days. However, the condition of renal function should be checked carefully before and after intake of
Contraindication: Ofloxacin is not recommended in all conditions. The
medication can be contraindicated in the following cases:
Patient having a liver
Patient is pregnant or a lactating
Patient having a psychiatric
Patient suffering from
Patient belongs to pediatric
Patient suffering from any sexually
Patient feeling uneasy after being
administered by this drug
Mechanism of Action (MOA): Being a broad-spectrum antibiotic, Ofloxacin is effective
against both gram-positive and gram-negative bacteria. Its main function is to first inhibit the DNA gyrase and
topoisomerase IV, thereby restricting cell division. Some of the derivatives of this drug display high activity
against bacterial topoisomerase and eukaryotic topoisomerase, thus restricting bacterial growth.
– Having a bio-availability of 98%, it gets
readily absorbed after oral intake.
– When administered to healthy elderly
people, the maximum plasma concentrations were usually reached within 1-2 hours, showing the rapid distribution
of the drug.
– Most of the drug remains unaffected by the
human metabolic processes
– Between 65-80% of orally administered
Ofloxacin remains untouched when it is excreted through urination after nearly 48 hours from its
administrations. 5% of it is recovered in the urine as N-oxide metabolites. 4-8% of it is excreted in
Interactions: Ofloxacin reacts with a number of other drugs, including
some herbal and certain food supplements - st John wort for instance. It is said to react with the drugs like
acenocoumarol, anisindione, dicumarol, dihydroquinidine barbiturate, quinidine, and quinidine
Side Effects: Ofloxacin can cause serious side effects. It is reported
to have caused peripheral neuropathy (irreversible nerve damage), tendon damage, heart problems, and pseudomembranous colitis (not to be confused with ulcerative colitis. Damage to liver and dysglycemia are also some of the other side
effects of this drug. Hepatotoxicity has also been reported in some cases that may result in severe after
effects. On experiencing any of these side effects doctor must be consulted immediately.